Input-specific control of interneuron numbers in nascent striatal networks

• DOI: 10.1073/pnas.2118430119
• Publication Date: 2022-05-09T19:03:16Z
• Authors: Varun Sreenivasan; Eleni Serafeimido...; David Exposito-Al...; Kinga Bercsenyi; Clémence Bernard; Sung-Eun Bae; Fazal Oozeer; Alicia Hanusz-Godoy; Robert H. Edwards; Oscar Marín
• Keywords: Interneuron; Medium spiny neuron; Nerve net

Significance Brain function requires appropriate numbers of different neuronal subtypes, but how these are established remains poorly understood. Here, we identified a key role for the cerebral cortex in remotely controlling interneuron survival and thus establishing two main types interneurons another brain region, striatum. While cortical pyramidal cells directly control parvalbumin-expressing GABAergic neurons, cholinergic is indirectly controlled through activity striatal medium spiny neurons. Our results demonstrate that input-specific modulation universally required to across very circuits. This important assembly balanced neural networks.