Carcinomas assemble a filamentous CXCL12–keratin-19 coating that suppresses T cell–mediated immune attack

• DOI: 10.1073/pnas.2119463119
• Publication Date: 2022-01-19T22:20:49Z
• Authors: Zhikai Wang; Philip Moresco; Ran Yan; Jiayun Li; Ya Gao; Daniele Biasci; Min Yao; Jordan Pearson; Jaclyn F. Hechtman; Tobias Janowitz; Raza M. Zaidi; Matthew J. Weiss; Douglas T. Fearon
• Keywords: Segmented filamentous bacteria

Significance Carcinomas resist immunotherapy because T cells are absent from nests of cancer cells. The chemokine/chemokine receptor system, which regulates the migration immune cells, is a candidate for this impaired intratumoral accumulation Cancer in human pancreatic, colorectal, and breast cancers coated with chemokine CXCL12 form covalent heterodimers keratin-19. This coating was investigated using mouse model pancreatic that replicates immunological characteristics cancer. Mouse without formed tumors did not exclude responded to anti–PD-1 antibody treatment. Thus, ability coat themselves may contribute resistance immunotherapy.