SNAT7 regulates mTORC1 via macropinocytosis

• DOI: 10.1073/pnas.2123261119
• Publication Date: 2022-05-13T18:43:56Z
• Authors: Delong Meng; Qianmei Yang; Mi-Hyeon Jeong; Adna Curukovic; Shweta Tiwary; Chase H. Melick; Tshering D. Lama-...; Huanyu Wang; Mariela Huerta-Ro...; Greg Urquhart; Lauren G. Zacharias; Cheryl Lewis; Ralph J. DeBerard...; Jenna L. Jewell
• Keywords: RHEB

Significance The mammalian target of rapamycin complex 1 (mTORC1) signaling pathway is frequently elevated in human disease, including cancer, type 2 diabetes, metabolic disorders, and neurodegeneration. We identify SNAT7 as an important regulator mTORC1. believe this research will provide valuable insight about mTORC1 biology may uncover novel therapeutic targets for patients.