Engineered calprotectin-sensing probiotics for IBD surveillance in humans

• DOI: 10.1073/pnas.2221121120
• Publication Date: 2023-07-31T19:07:46Z
• Authors: Jonathan Y. Xia; Chelsea Hepler; Peter Tran; Nathan J. Waldeck; Joseph Bass; Arthur Prindle
• Keywords: Faecal calprotectin

Inflammatory bowel disease (IBD) is a spectrum of autoimmune diseases affecting the gastrointestinal tract characterized by relapsing and remitting course gut mucosal inflammation. Disease flares can be difficult to predict, current practice IBD activity surveillance through endoscopy invasive requires medical expertise. Recent advancements in synthetic biology raise possibility that symbiotic microbes engineered selectively detect biomarkers used clinical practice. Here, we introduce an probiotic capable detecting gold standard biomarker, calprotectin, with sensitivity specificity patients. Specifically, identified bacterial promoter strain