LactobacillusFirm-5-derived succinate prevents honeybees from having diabetes-like symptoms

• DOI: 10.1073/pnas.2405410121
• Publication Date: 2024-08-26T19:05:06Z
• Authors: Benfeng Han; Jiawei Hu; Chengfeng Yang; Junbo Tang; Yating Du; Lizhen Guo; Yashuai Wu; Xue Zhang; Xin Zhou
• Keywords: Gut–brain axis

The gut microbiome plays an important role in honeybee hormonal regulation and growth, but the underlying mechanisms are poorly understood. Here, we showed that depletion of bacteria resulted reduced expression insulin-like peptide gene ( ilp ) head, accompanied by metabolic syndromes resembling those Type 1 diabetes humans: hyperglycemia, impaired lipid storage, decreased metabolism. These symptoms were alleviated bacterial inoculation. Gut metabolite profiling revealed succinate, produced Lactobacillus Firm-5, played deterministic roles activating regulating metabolism honeybees. Notably, demonstrated succinate modulates host through stimulating gluconeogenesis, a mechanism humans. This study presents evidence for modulating contributes to understanding interactions between bee hosts.