Activation of the c-mos oncogene in a mouse plasmacytoma by insertion of an endogenous intracisternal A-particle genome.

• DOI: 10.1073/pnas.80.23.7118
• Publication Date: 2006-05-31T09:16:22Z
• Authors: E Canaani; O Dreazen; A Klar; G Rechavi; D Ram; J B Cohen; D Givol
• Keywords: Insertion sequence; Coding region; Alu element; Homology

The activation of the cellular oncogene c-mos in mouse plasmacytoma XRPC24 was found to result from insertion a 4.7-kilobase-pair DNA element, within coding region. element terminates on both sides with direct repeat around 335 nucleotides. as well internal sequences show strong homology endogenous intracisternal A-particle (IAP) genes. IAP genome integrated head-to-head (5' 5') configuration. This juxtapositioned 5' long terminal next bulk oncogene's region and shifted flanking position further upstream. significance several aspects this transposition event is discussed.