Vitamin D metabolites change the phenotype of monoblastic U937 cells.

• DOI: 10.1073/pnas.80.24.7538
• Publication Date: 2006-05-31T09:18:18Z
• Authors: R C Dodd; M S Cohen; S L Newman; T K Gray
• Keywords: U937 cell; Monocyte

U937 is a human-derived lymphoma cell line that has monoblastic properties and high-affinity receptors for 1 alpha,-dihydroxyvitamin D3. Incubation of these cells with the vitamin D metabolite at 10 nM 5 days produced marked stimulation in adherence ingestion Staphylococcus aureus (645% control) C3b receptor (CR1) expression (292% slight increase hexose monophosphate shunt activity without changing growth rates or Fc fragment expression. The changes cellular association S. CR1 were detected as early 48 hr incubation peaked between 3 days. Similar induced by 25-hydroxy- 24,25-dihydroxyvitamin D3 micromolar concentrations. Dexamethasone, hydrocortisone, progesterone had no effect on incubated presence metabolites exhibited change their phenotype. These results suggest may contribute to monocyte/macrophage differentiation.