Human B-cell differentiation factor defined by an anti-peptide antibody and its possible role in autoantibody production.

• DOI: 10.1073/pnas.84.1.228
• Publication Date: 2006-05-31T10:17:19Z
• Authors: T Hirano; T Taga; K Yasukawa; K Nakajima; N Nakano; F Takatsuki; M Shimizu; A Murashima; S Tsunasawa; F Sakiyama
• Keywords: 0301 basic medicine; B-Lymphocytes; Lymphokines; Immune Sera; Antibodies; Chromatography, Affinity; Cell Line; 3. Good health; 03 medical and health sciences; Humans; Amino Acid Sequence; Interleukin-4; Growth Substances; Autoantibodies

The partial amino acid sequence of the NH2 terminus a factor named human B-cell differentiation or stimulatory 2 (BSF-2) has been determined. Antibodies raised against synthetic peptide corresponding to residues 1-13 NH2-terminal specifically react with BSF-2 generated by T-cell line and phytohemagglutinin-stimulated normal T cells. Furthermore, antipeptide antibodies BSF-2-like produced cardiac myxoma as well uterine cervical carcinoma results show that functions in vivo suggest constitutive production may be involved autoantibody production, since patients showed production.