Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line.

• DOI: 10.1073/pnas.84.10.3434
• Publication Date: 2006-05-31T10:18:53Z
• Authors: D J Drucker; J Philippe; S Mojsov; W L Chick; J F Habener
• Keywords: Proglucagon; Insulin oscillation

Insulin secretion is controlled by a complex set of factors. Although blood glucose levels serve as the major stimulus insulin in mammals, release also modulated amino acids, catecholamines, glucagon, and other, intestinal hormones. The identification factors that modulate production has engendered much interest because their potential importance altered dynamics response to characteristic maturity-onset diabetes mellitus. Decoding glucagon gene uncovered two additional glucagon-like peptides encoded proglucagon, polypeptide precursor glucagon. One these peptides, peptide I, processed from proglucagon forms, 31 37 acids. We report smaller potently increases cAMP levels, mRNA transcripts, cultured rat insulinoma cells. These results indicate I may be physiologic modulator expression.