Long-term observations of autoimmune-prone mice treated for autoimmune disease by allogeneic bone marrow transplantation.

• DOI: 10.1073/pnas.86.9.3306
• Publication Date: 2006-05-31T11:17:33Z
• Authors: S Ikehara; R Yasumizu; M Inaba; S Izui; K Hayakawa; K Sekita; J Toki; K Sugiura; H Iwai; T Nakamura
• Keywords: Histocompatibility; Minor histocompatibility antigen

Long-term effects of allogeneic bone marrow transplantation (ABMT) across major histocompatibility complex barriers were studied in (NZB x NZW)F1 (B/W), BXSB, and MRL/Mr-lpr-lpr (MRL/lpr) mice with established autoimmune disease at the time ABMT. In BXSB or B/W mice, ABMT cured all aspects disease. Glomerular damage, revealed by histological study was dramatically improved. Serological abnormalities immunologic functions also normalized. Correction advanced renal regularly lasted greater than 5-6 mo even 1 yr after MRL/lpr however, first improved but then recurred ABMT, apparently because intolerance for high doses irradiation a degree resistance recipient stem cells to irradiation. this model, H-2 typing that relapse, immunocompetent chimeric had been replaced host (MRL/lpr; H-2k) cells. B220+ Ly-1+ cells, present increased numbers untreated initially returned normal levels reappeared received from donors having few such lymphocytes. Thus, our results show possess abnormal radioresistant provide impressive evidence origin diseases strain, as several other strains studied, residues