Evidence for an involvement of the brain cholecystokinin B receptor in anxiety.

• DOI: 10.1073/pnas.88.4.1130
• Publication Date: 2006-05-31T11:53:31Z
• Authors: L Singh; A S Lewis; M J Field; J Hughes; G N Woodruff
• Keywords: Pentagastrin; Anxiogenic; Cholecystokinin B receptor; Pentylenetetrazol

The effect of neuropeptide cholecystokinin (CCK) receptor agonists and antagonists was examined in the rat elevated X-maze model anxiety. selective CCK-B CI-988 (PD 134308) L-365,260 produced anxiolytic-like effects, whereas MK-329, a CCK-A antagonist, respectively less potent by factors 313 200. intracerebroventricular administration nonselective CCK agonist caerulein or pentagastrin increased dose dependently level antagonized anxiogenic response to but not that induced pentylenetetrazol. These results strongly suggest activation brain induces anxiety this represent separate class anxiolytic agents.