Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates.

• DOI: 10.1073/pnas.91.8.3147
• Publication Date: 2006-05-31T13:08:01Z
• Authors: Y Zhang; T W Kensler; C G Cho; G H Posner; P Talalay
• Keywords: Sulforaphane; Inducer; Anticarcinogen

Sulforaphane [1-isothiocyanato-4-(methyl-sulfinyl)butane] was recently isolated from one variety of broccoli as the major and very potent inducer phase 2 detoxication enzymes in murine hepatoma cells culture. Since enzyme induction is often associated with reduced susceptibility animals their to toxic neoplastic effects carcinogens other electrophiles, it important establish whether sulforaphane could block chemical carcinogenesis. In this paper we report that three synthetic analogues, designed inducers, formation mammary tumors Sprague-Dawley rats treated single doses 9,10-dimethyl-1,2-benzanthracene. The analogues are exo-2-acetyl-exo-6-isothiocyanatonorbornane, endo-2-acetyl-exo-6-isothiocyanatonorbornane, exo-2-acetyl-exo-5-isothiocyanatonorbornane. When exo-2-acetyl-exo-6-isothiocyanatonorbornane were administered by gavage (75 or 150 mumol per day for 5 days) around time exposure carcinogen, incidence, multiplicity, weight significantly reduced, development delayed. endo-2-acetyl-exo-6-isothiocyanatonorbornane exo-2-acetyl-exo-5-isothiocyanatonorbornane less protectors. Thus, a class functionalized isothiocyanates anticarcinogenic properties has been identified. These results validate thesis inducers cultured likely protect against