Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation

• DOI: 10.1073/pnas.96.4.1457
• Publication Date: 2002-07-26T14:42:40Z
• Authors: Koichi Kobayashi; Masahiko Hatano; Masayuki Otaki; Takeshi Ogasawara; Takeshi Tokuhisa
• Keywords: Survivin; Inhibitor of apoptosis

The inhibitor of apoptosis (IAP) proteins form a highly conserved gene family that prevents cell death in response to variety stimuli. Herein we describe newly defined murine IAP, designated Tiap, proved be homologue human survivin based on sequence comparison. TIAP has one baculovirus IAP repeat and lacks C-terminal RING finger motif. interacted with the processed caspase 3 inhibited caspase-induced death. Histological examinations revealed is expressed growing tissues such as thymus, testis, intestine adult mice many embryos. In vitro studies, was induced splenic T cells activated anti-CD3 antibody or Con A, expression up-regulated synchronized NIH 3T3 at S G 2 /M phase cycle. We propose during proliferation, cellular protective activity may augmented inducible IAPs TIAP.