Differential Interactions of the CREB/ATF Family of Transcription Factors with p300 and Adenovirus E1A

• DOI: 10.1074/jbc.271.30.17666
• Publication Date: 2002-07-26T15:07:12Z
• Authors: Jeng-Shin Lee; Xiaolin Zhang; Yang Shi
• Keywords: Transcription

The adenovirus E1A-associated protein p300 is a transcriptional cofactor that interacts with YY1 and mediates the relief of repression by E1A. These observations raise possibility may function as bridging factor between E1A cellular transcription factors. Here we show p300, but not mutant defective for binding to E1A, activated cAMP-responsive element-binding protein/activating (CREB/ATF) site-mediated in presence Among proteins can recognize CREB/ATF site, CREB appeared be modulated binding-dependent manner. This effect was correlated specific physical interaction p300. results suggest plays crucial role mediating functional interplay certain members family. Two separate domains within were identified are capable activating transcription. One interacted basal TFIIB, suggesting coactivator making contacts both sequence-specific factors machinery. pivotal make it prime target viral such programming