Persistent Staphylococcus aureus bacteremia: Incidence and outcome trends over time

• DOI: 10.1080/00365540802441711
• Publication Date: 2008-09-26T17:04:24Z
• Authors: Riad Khatib; L. B. Johnson; M. Sharma; M. G. Fakih; R. Ganga; K. Riederer
• Keywords: Bacteremia

Persistent Staphylococcus aureus bacteremia (SAB-P) is well known but poorly delineated due to unclear definition. We retrospectively studied 78 patients with SAB-P using a stringent definition (bacteremia for > or = 7 d), in single teaching hospital, during 1 January 2002 30 June 2003 and November 2005 31 December 2006 determine whether the frequency, risk factors outcome changed over time. SAB was encountered 354 259 instances 2 periods, respectively. Patients' characteristics increasing organ dysfunction score (2.9+/-1.7 vs 3.4+/-1.4; p <0.001), invasive devices (27.7% 41.3%; p=0.001), hemodialysis dependence (19.2% 27.8%; p=0.04), MRSA (50.8% 64.5%; vancomycin treatment (57.9% 67.2%; p=0.02). frequency increased slightly (11.0% 15.1%). Risk (associated) (identified by logistic regression) were metastatic infection (OR=5.60; 95% CI 3.00 - 10.47), (OR=4.17; 2.14 8.11), endovascular sources (OR=3.35; 1.92 5.85) diabetes (OR=2.14; 1.26 3.64). SAB- SAB-P-associated case-fatality did not change (23.2% 18.5% 25.6 30.8%, respectively). All survivors ultimately achieved clearance. These findings suggest that are changing Additionally, higher than previously reported. rise probably SAB, MRSA, at complications. Innovative approaches should target novel modalities reduction.