Synthesis of polysubstituted pyrazoles and their biological applications

• DOI: 10.1080/00397911.2024.2377283
• Publication Date: 2024-07-12T05:53:49Z
• Authors: Appalanaidu Satip...; Ramakrishna Rao B...; Ramana Tamminana
• Keywords: 01 natural sciences; 0104 chemical sciences

Novel library of pyrazole derivatives (6a–k) from substituted 4-dioxaborolanyl-1H-pyrazole and halo benzaldehyde through simultaneous Suzuki reaction, nucleophilic addition, and hydrolysis under moderate reaction conditions. The desired compounds 6a–k have been formed in good to high yield. All the compound structures were characterized by analytical and spectral (1H NMR,13C NMR and MS) studies. Furthermore, the evaluation of biological activity of synthesized molecules.