Toxicological effects of the Morinda citrifolia L. fruit extract on maternal reproduction and fetal development in rats

• DOI: 10.1080/01480545.2022.2070197
• Publication Date: 2022-05-03T06:43:06Z
• Authors: Thaís Leal-Silva; Maysa Rocha Souza; Larissa Lopes Cruz; Rafaianne Queiroz...; Verônyca Gonçalve...; Thaigra Sousa Soares; Vanessa Dela Justina; Fernanda Regina G...; Débora Cristina D...; Madileine Francel...; Gustavo Tadeu Vol...
• Keywords: Morinda

Morinda citrifolia L., also known as Noni, is widely used plant in folk medicine for various therapeutic purposes. However, reports on its effects during pregnancy are limited. Therefore, the objective of this study was to evaluate M. fruit extract maternal performance and fetal development rats. Pregnant Wistar rats (n = 12/group) were treated from gestational days (GD) 0-21 with water (control group) or aqueous at doses 200, 400, 750 mg/kg, orally. During pregnancy, clinical signs toxicity, weight, feed intake, consumption noted. On GD 21, anesthetized blood collected biochemical parameters. laparotomy, reproductive parameters recorded, fetuses weighed anomalies analyzed. Reduced placental efficiency growth restriction observed group 400 mg/kg extract. The highest dose (750 mg/kg) augmented aspartate aminotransferase concentration preimplantation losses, while reducing number live fetuses. Furthermore, both (400 caused anomalies. In conclusion, high extrac leads hepatotoxicity, anti-implantation effects, intrauterine abnormalities, indicating that can be harmful mother fetus.