Enzymatic synthesis of chiral alcohols using ketoreductases

• DOI: 10.1080/01614940.2024.2313603
• Publication Date: 2024-02-19T12:00:35Z
• Authors: Quan Yuan; Li Ma; Weixi Kong; Jianqiao Liu; Shuling Zhang; Jiajing Yan; Jing Bai; Ying He; Liya Zhou; Yunting Liu; Yanjun Jiang

Ketoreductases(KREDs), which play an important role in the preparation of chiral alcohol drug intermediates, are promising biocatalysts that can lead to become a greener and more sustainable process. Two decades ago, KREDs were widely researched from protein structure catalytic mechanism, many researchers worked on properties research. And with engineering development, useful production This review has summarized applications, perspective biocatalysis, providing detailed introduction different KRED structures as well enzyme library construction bioreactor applications.