Semi-Purified Saponins of Holothuria poli Associated Antiproliferation in Tumor Cell Lines

• DOI: 10.1080/01635581.2021.1952630
• Publication Date: 2021-08-28T10:02:30Z
• Authors: Nazli Mert-Ozupek; Yasemin Basbinar; Tugba Uysal-Kilic; Omer Koz; Hulya Ellidokuz; Levent Cavas
• Keywords: Cancer cell lines; IC50

The incidence of cancer has exhibited an increasing trend in recent years because many reasons such as environmental and nutritional factors. There is a great need for the development new natural molecules with lower side effects therapy cancer. It was aimed to evaluate antiproliferative effect semi-purified triterpene glycosides Holothuria poli on different human cell lines. body walls H. main sources saponins were used saponin content extract characterized by MALDI-TOF/MS. antiproliferation activity tested showed studied mass analysis results reveal that Holothurin A one within extract. measured IC50 values found 31.41 ± 2.20, 77.45 0.23, 34.79 0.90 µg mL−1 HT-29, UPCI-SCC-131, T84 lines, respectively. secretes not only specific but also cocktail them. Specific versus. cocktails applying organic modification must be further research understand their mechanisms studies since this paper reveals promising results.