Comparison of Hematopoietic Stem Cell Transplantation Results in Patients with β-Thalassemia Major from Three Different Graft Types

• DOI: 10.1080/03630269.2021.1872611
• Publication Date: 2021-01-22T05:20:11Z
• Authors: Selime Aydogdu; Ersin Toret; Basak A. Aksoy; Muhammed Fatih Aydın; Funda E. Cipe; Ceyhun Bozkurt; Tunc Fisgin
• Keywords: Univariate analysis; Cord blood

Allogeneic hematopoietic stem cell transplantation (HSCT) is the curative therapy for β-thalassemias that induces severe life-threatening complications. The human leukocyte antigen (HLA) registries and umbilical cord blood banks have carried out diligent searches to find matched unrelated donors (MUDs) about 70.0% of patients from 2000 onwards. chance finding a non-sibling fully family higher in some ethnic groups which consanguineous marriages are common. We studied compared transplant complications outcomes different graft types (sibling, unrelated). donor (MFD) group consisted four mothers, three fathers, five cousins, one paternal uncle aunt. There was no significant difference mean transfused CD34+ cells, engraftment, median days neutrophil platelet recovery were achieved (p > 0.05). distribution postttransplant complication did not show any between In univariate analysis multivarite analyses, age, gender, Pesaro risk (I-II vs. III) ABO incompatibilty demonstrated disease free survival < Furthermore, second step investigating overall (OS), gender showed transplant-related mortality (TRM) groups. Non-sibling related transplants important populations where Transplant according type had similar thalassemia-free (TFS) OS when using treosulfan-based regimen our study.