Urinary organic acids spectra in children with altered gut microbiota composition and autistic spectrum disorder

• DOI: 10.1080/08039488.2021.2014954
• Publication Date: 2021-12-22T15:15:41Z
• Authors: Zanda Daneberga; Miki Nakazawa-Mik...; Egija Berga-Svitina; Daiga Murmane; Dana Isarova; Liene Cupane; Madara Masinska; Inga Nartisa; Andzela Lazdane; Edvins Miklasevics
• Keywords: Dysbiosis

Introduction: Alteration of human gut microbiota is described in a number neuro-developmental and cognitive disorders including autistic spectrum disorder (ASD). Along with the changes microbiota, children ASD are also reported to have urinary organic acid spectra implying these metabolites as potential biomarkers for gastrointestinal dysbiosis.Aim: Identify that would indicate specific could be useful biomarkers.Methods: The study group consisted 44 ASD. Urinary acids composition were analysed.Results: Any significant deviation quantified compared reference values not confirmed. main variations detected concentration p-cresol 3-(3-hydroxyphenyl)-3-hydroxypropionic (HPHPA), but we cannot confirm presence HPHPA urine biomarker Clostridium sp. overgrowth gut. acquired results higher relative abundance Firmicutes phylum alone may attributed increased urine. Decreased Bacteroidetes/Firmicutes ratio was found urine.Conclusions: Metabolites can used alterations caution, guided treatment should administrated only based on analysis or combination results, solely biomarkers.