Association between the gut microbiota and diabetic nephropathy: a two-sample Mendelian randomization study

• DOI: 10.1080/0886022x.2024.2357746
• Publication Date: 2024-06-04T08:47:41Z
• Authors: Wenjie Dong; Qiuyu Li; Lei Chen; Hui Tang; Kun Tu; Li Luo; Longyang Jiang; Yilan Huang
• Keywords: Mendelian Randomization; Genome-wide Association Study; Genetic Association

Numerous studies have revealed a correlation between the risk of developing diabetic nephropathy (DN) and gut microbiota (GM) composition. However, it remains uncertain whether GM composition causes DN. We aimed to explore any potential causal links A meta-analysis conducted by MiBioGen consortium largest genome-wide association study (GWAS) provided aggregated data on GM. DN were obtained from IEU database. The inverse-variance weighting (IVW) method was employed as primary analytical approach. IVW analysis indicated that genus Dialister (OR = 0.51, 95% CI: 0.34–0.77, p 0.00118) protective against In addition, class Gammaproteobacteria 0.47, 0.27–0.83, 0.0096), Lentisphaeria =0.76, 0.68–0.99, 0.04), order Victivallales 0.76, 0.58–0.99, phylum Proteobacteria 0.53, 0.33–0.85, 0.00872) negatively associated with Genus LachnospiraceaeUCG008 =1.45, 1.08–1.95, 0.01), Bacteroidales 1.59, 1.02–2.49, Terrisporobacter 1.98, 1.14–3.45, 0.015) positively this study, we established relationship Further trials are required confirm effects probiotics elucidate precise mechanisms involving