First report of isolation of maleamic acid from natural source Polygonatum cirrhifolium—A potential chemical marker for identification

• DOI: 10.1080/10826076.2017.1402185
• Publication Date: 2017-12-05T14:35:05Z
• Authors: Jaswinder Kaur Virk; Parveen Bansal; Vikas Gupta; Sanjiv Kumar; Ranjit Singh; Ravindra Kumar Rawal
• Keywords: Natural compound

Polygonatum cirrhifolium (Meda) plant is being used in number of rejuvenating Ayurvedic formulations. Ever rising demands, lack natural sources, and insufficient quantity, to meet the requirements market, raw material has led toward use official substitutes recommended by Department AYUSH that further encouraged manufacturers for adulteration formulations other substandard/spurious drugs. Literature reveals more than 60% parameters as well pharmacological actions Ashtawarga plants do not match with their leading reduced efficacy drugs along loss faith herbal Consumers are forced pay which never been high-cost claimed formulation. The situation exploited because regulatory authorities tools (marker compound) needed identification authentic plant. Methanolic extract rhizomes was subjected column chromatography. Isolated compound characterized (Z)-4-amino-4-oxobut-2-enoic acid (maleamic acid/maleamate/maleic monoamide/maleic monoamide) chemical test, melting point, IR/NMR/mass/UV spectral analysis. It first report genus can be a marker market