Evaluation of the health economic impact of initial diagnostic modality selection in patients suspected of having HCC in China and the USA

• DOI: 10.1080/13696998.2022.2110353
• Publication Date: 2022-08-05T21:03:29Z
• Authors: Michael Blankenburg; Mostafa Elhamamy; Diana Zhang; Alice Corbin; Guanyi Jin; James Harris; Gesine Knobloch
• Keywords: Modality (human–computer interaction)

To compare relative costs associated with the diagnostic pathways for hepatocellular carcinoma (HCC) in US and China according to initial imaging modality used. Gadoxetate disodium (ethoxylbenzyl-diethylenetriaminepentaacetic acid)-enhanced magnetic resonance (EOB-MRI) was compared contrast-enhanced multidetector computed tomography (MDCT), extracellular contrast media enhanced-MRI (ECCM-MRI) ultrasound (CEUS).Decision tree models were developed simulate clinical pathway, based on local guidelines, validated by experts. Input data derived from literature (up 31 December 2020) as well interviews experts.The showed that alternative modalities, EOB-MRI higher accuracy (fewer false-positive fewer false-negative results). Increasing proportionate use of resulted a cost offset per patient (excluding patients) both (USD 337) (CNY 1,443), driven reductions scan unnecessary treatment costs. The also shorter average waiting time final diagnosis decision patients MDCT, ECCM-MRI, CEUS.The findings these demonstrate is most accurate rapid HCC China, resulting offsets may benefit healthcare system.