Chronic whole-body heat treatment in obese insulin-resistant C57BL/6J mice

• DOI: 10.1080/13813455.2024.2406904
• Publication Date: 2025-03-28T05:05:56Z
• Authors: Helena Trevisan S...; Carlos Henrique d...; Maria Inês Lavina...; Marcela Alves de ...; Victor de Souza B...; Cristiana Maria S...; Paulo Ivo Homem d...

This study examined the effects of hyperthermic therapy (HT) on mice fed normal chow or a high-fat diet (HFD) for 18 22 weeks, undergoing four eight weekly HT sessions. Mice were housed within their thermoneutral zone (TNZ) to simulate physiological response. HFD-induced obesity-related changes, including weight gain, visceral fat accumulation, muscle loss (indicative obesity sarcopenia), glucose intolerance, and hepatic triglyceride buildup. upregulated HSP70 expression in muscles, mitigated normalised QUICK index, reduced plasma concentrations. It also lowered H-index balance, indicating improved immunoinflammatory status, decreased activated caspase-1 proliferative senescence adipose tissue, both linked insulin resistance. The findings suggest that even animals "control" but with insufficient physical activity TNZ may experience impaired glycaemic homeostasis.