Advances in drug treatments for mesothelioma

• DOI: 10.1080/14656566.2022.2072211
• Publication Date: 2022-05-05T00:56:37Z
• Authors: Paolo Andrea Zucali; Fabio De Vincenzo; Matteo Perrino; Nunzio Digiacomo; Nadia Cordua; Federica D’Antonio; Federica Borea; Roberta Fazio; Angelo Pirozzi; Armando Santoro
• Keywords: Targeted Therapy

The paucity of the therapeutic armamentarium currently available for patients with malignant mesothelioma clearly represents a huge unmet need. Over last years, based on new advances in understanding biology mesothelioma, approaches have been investigated.In this manuscript, literature data regarding drug treatment are critically reviewed, focusing particularly immunotherapy and targeted therapy.The latest findings therapy changing mesothelioma. However, comprises genomically different subtypes phenotypic diversity combined rarity disease major criticality developing effective therapies. Although first clinical encouraging, treatment's stratification by molecular characteristics is only at beginning. Luckily, rapid improvement producing opportunities discovering targets to test pre-clinical settings transfer setting. In evolving scenario, future perspectives seem really promising.