Chemical constituents of Impatiens chapaensis Tard. and their α-glucosidase inhibition activities

• DOI: 10.1080/14786419.2021.1956923
• Publication Date: 2021-09-09T12:51:50Z
• Authors: Nguyen Thi Thuy Linh; Trinh Thi Thuy; Nguyen Thanh Tam; Ba Thi Cham; Khieu Thi Tam; Nguyen Hoang Sa; Do Thi Thao; Vu Tien Chinh; Nguyen Thi Hoang Anh
• Keywords: Flavonoids; Plant Extracts; Phytochemicals; Glycoside Hydrolase Inhibitors; alpha-Glucosidases; Impatiens; 01 natural sciences; 3. Good health; 0104 chemical sciences

Sixteen compounds (1-16) were isolated from Impatiens chapaensis. Chemical structures were determined by spectroscopic analyses and comparisons with previously published data. This report is the first to identify compounds 1, 5–7, 10, 12–14, and 16 from the genus Impatiens. Seven chosen isolates (5, 7, 10, 11, 12, 15, and 16) were submitted for α-glucosidase inhibition assays with acarbose as the positive control (IC50 = 227.14 ± 13.71 µM). Flavonoid 5 exhibited a significant inhibitory effect (IC50 = 101.00 ± 9.01 µM).