VMP1 regulates hepatic lipoprotein secretion and NASH independent of autophagy

• DOI: 10.1080/15548627.2022.2080958
• Publication Date: 2022-05-26T17:05:07Z
• Authors: Xiaoxiao Jiang; Allen Chen; Wen-Xing Ding; Hong-Min Ni
• Keywords: Phosphatidylethanolamine; Phospholipid scramblase; Steatohepatitis

VMP1 is an ER membrane protein with phospholipid scramblase activity that has a critical role in regulating phagophore expansion and autophagosome closure. also regulates lipid droplet formation lipoprotein secretion cultured cells zebrafish. In recent study, we showed mice hepatic deletion of Vmp1 have impaired very-low-density (VLDL) develop nonalcoholic steatohepatitis (NASH) even when fed regular chow diet. Mechanistically, leads to decreased phosphatidylcholine (PC) phosphatidylethanolamine (PE) levels as well altered PC PE acyl chain compositions resulting the accumulation neutral structures bilayer pre-VLDL assembly. These studies provide novel mechanistic insights into non-autophagic functions secretion.