GABA Supplementation, Increased Heart-Rate Variability, Emotional Response, Sleep Efficiency and Reduced Depression in Sedentary Overweight Women Undergoing Physical Exercise: Placebo-Controlled, Randomized Clinical Trial

• DOI: 10.1080/19390211.2024.2308262
• Publication Date: 2024-02-07T06:19:10Z
• Authors: Aparecida Patrici...; Helen Seidel; Larissa Vitalina ...; Cristina Oliveira...; Raianne dos Santo...; Perciliany Martin...; Fernanda Guimarãe...; Daniel Barbosa Co...; Lenice Kappes Becker; Emerson Cruz de O...
• Keywords: Depression

Gamma-aminobutyric acid (GABA) serves as a pivotal neurotransmitter implicated in the pathogenesis of stress, anxiety, sleep-related disorders, and heart rate (HR) reactions. Heart-rate variability (HRV), modulated by sympathetic parasympathetic branches autonomic nervous system (ANS), offers insights into cardiac control cardiovascular well-being. The present study aimed to explore impact GABA supplementation on emotional metrics, sleep quality, HRV sedentary women with overweight or obesity partaking physical exercise. A randomized, double-blind, placebo-controlled clinical trial was undertaken involving 30 obesity. Volunteers were assigned randomly two groups: intervention group receiving (200 mg) once daily for total 90 doses, placebo group. Both groups engaged exercise, while regimen spanned days. Assessments conducted at three intervals: baseline (T0), midway through (T45), culmination (T90). Following days supplementation, demonstrated enhancements habitual efficiency, indicated reductions Pittsburgh Sleep Quality Index (PSQI) scores. Moreover, an improved response observed, characterized diminished negative affect. yielded ameliorations depression scores per Depression, Anxiety, Stress Scale (DASS-21). Notably, augmented noted, attributed heightened predominance. elicited noteworthy variability, response, mitigation, efficiency following 90-day supplementation.