Modeling spatial interaction networks of the gut microbiota

• DOI: 10.1080/19490976.2022.2106103
• Publication Date: 2022-08-03T18:45:52Z
• Authors: Xiaocang Cao; Ang Dong; Guangbo Kang; Xiaoli Wang; Liyun Duan; Huixing Hou; Tianming Zhao; Shuang Wu; Xinjuan Liu; He Huang; Rongling Wu
• Keywords: Dysbiosis; Causality; Mutualism; Temporal scales

How the gut microbiota is organized across space postulated to influence microbial succession and its mutualistic relationships with host. The lack of dynamic or perturbed abundance data poses considerable challenges for characterizing spatial pattern interactions. We integrate allometric scaling theory, evolutionary game prey-predator theory into a unified framework under which quasi-dynamic networks can be inferred from static data. illustrate that such capture full properties interactions, including causality, sign strength, feedback loop, are dynamically adaptive along gradients, context-specific, variability between individuals within same individual time space. design conduct study validate model, key determinants differences ulcerative colitis healthy controls. Our model provides sophisticated means unraveling complete atlas how interactions vary quantifying causal change in health state.