Adjuvant polyarthritis. V. Induction by N-acetylmuramyl-L-alanyl-D-isoglutamine, the smallest peptide subunit of bacterial peptidoglycan.

• DOI: 10.1084/jem.153.4.1021
• Publication Date: 2004-06-23T21:00:50Z
• Authors: Y H Chang; C M Pearson; L Chedid
• Keywords: Male; 610; Peptidoglycan; Mice; 03 medical and health sciences; Strains:; Adjuvants, Immunologic; 616; Animals; Pathology:; Neoplasm:; 0303 health sciences; Transplantation:; Arthritis; Glycopeptides; Intradermal Tests; Arthritis, Experimental; Transplantable Tumors:; Rats; 3. Good health; Mice, Inbred C57BL; Types of Tumors:; Rats, Inbred Lew; Peptides; Serology:; Acetylmuramyl-Alanyl-Isoglutamine

N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP), an apparently nonimmunogenic bacterial peptidoglycan-derived small peptide, was found to induce a polyarthritis the rat similar that induced by Freund's complete adjuvant when injected in form of oil emulsion. An emulsion its isomer, N-acetylmuramyl-L-alanyl-L-isoglutamine, which unlike MDP has no immunostimulatory activity, failed disease.