Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells.

• DOI: 10.1084/jem.177.4.1199
• Publication Date: 2004-06-24T07:56:10Z
• Authors: R Manetti; P Parronchi; M G Giudizi; M P Piccinni; E Maggi; G Trinchieri; S Romagnani
• Keywords: T helper cell

The effects exerted on the in vitro development of antigen-specific T cell lines and clones by addition or neutralization interleukin 12 (IL-12) lymphocyte bulk culture were examined. specific for Dermatophagoides pteronyssinus group I (Der p I) derived presence IL-12 exhibited reduced ability to produce IL-4 increased interferon gamma (IFN-gamma), developed into Der I-specific CD4+ showing a helper type 0 (Th0)- Th1-, instead Th2-, like cytokine profile. In contrast, purified protein derivative (PPD)-specific anti-IL-12 antibody an PPD-specific Th0-, influence secretion profile was not prevented cultures anti-IFN-gamma antibody, but could be at least partially inhibited removal from CD16+ cells. Thus, cells appear have inhibitory IL-4-producing play inductive role promoting Th1-like responses.