Contribution of direct and indirect recognition pathways to T cell alloreactivity.

• DOI: 10.1084/jem.177.6.1643
• Publication Date: 2004-06-24T07:56:10Z
• Authors: Z Liu; Y K Sun; Y P Xi; A Maffei; E Reed; P Harris; N Suciu-Foca
• Keywords: Allorecognition; Priming (agriculture)

T cells from an HLA-DR11/DR12 responder were stimulated in mixed lymphocyte culture with carrying the DR1 antigen. After priming, proliferated response to both DR1-positive-stimulating and a peptide derived polymorphic region of HLA-DR beta 1*0101 chain presented by responder's antigen-presenting (APC). The dominant epitope recognized primed corresponded residue 21-42 was HLA-DR12 peptide-reactive express cell receptor V 3. results demonstrate that allopeptides processing presentation donor major histocompatibility complex molecules host-derived APC trigger alloreactivity. frequency engaged indirect pathway allorecognition is about 100-fold lower than participating direct recognition native However, may play important role chronic allograft rejection, phenomenon mediated activation helper alloantibody-producing B cells.