The type II "receptor" as a decoy target for interleukin 1 in polymorphonuclear leukocytes: characterization of induction by dexamethasone and ligand binding properties of the released decoy receptor.

• DOI: 10.1084/jem.179.2.739
• Publication Date: 2004-06-24T07:56:10Z
• Authors: F Re; M Muzio; M De Rossi; N Polentarutti; J G Giri; A Mantovani; F Colotta
• Keywords: Decoy; Interleukin-6 receptor; Interleukin-1 receptor

Whereas the signaling function of interleukin 1 (IL-1) receptor type I (IL-1R I) has been well documented, II "receptor" suggested to act as a decoy target for this cytokine. Since IL-1 may represent key immunomodulatory and antiinflammatory properties glucocorticoids (GC), aim study was investigate effects dexamethasone (Dex) on IL-1R expression in human polymorphonuclear leukocytes (PMN), which express predominantly molecule II). We found that Dex augments levels steady state transcripts encoding and, most prominently, those II. induced both via transcription-dependent mechanisms by prolongation mRNAs half-lives. Inhibition protein synthesis superinduced basal Dex-augmented mRNA, whereas it completely inhibited induction transcripts. Induction mRNA associated with augmented membrane release binding molecule. This effect mediated GC receptor. Other steroids (17 beta-estradiol, progesterone, testosterone) were ineffective. The concentrations alpha antagonist required displace beta soluble form from PMN were, respectively, 100 2 times higher compared beta. receptor, IL-1, contribute immunosuppressive activities Dex.