The Coordinated Action of CC Chemokines in the Lung Orchestrates Allergic Inflammation and Airway Hyperresponsiveness

• DOI: 10.1084/jem.188.1.157
• Publication Date: 2002-07-26T16:49:30Z
• Authors: Jose-Angel Gonzalo; Clare M. Lloyd; Danyi Wen; Juan P. Albar; Timothy N.C. Wells; Amanda Proudfoot; C. Martinez-A; Martin Dorf; Torbjörn Bjerke; Anthony J. Coyle; Jose-Carlos Gutie...
• Keywords: Allergic Inflammation; Bronchial hyperresponsiveness; Monocyte; Pathophysiology of asthma; CCR3

The complex pathophysiology of lung allergic inflammation and bronchial hyperresponsiveness (BHR) that characterize asthma is achieved by the regulated accumulation activation different leukocyte subsets in lung. development maintenance these processes correlate with coordinated production chemokines. Here, we have assessed role chemokines play BHR blocking their activities vivo. Our results show blockage each one reduces both infiltration a substantially way. Thus, eotaxin neutralization specifically eosinophilia transiently after antigen exposure. Monocyte chemoattractant protein (MCP)-5 abolishes not affecting inflammatory leukocytes airways, but rather altering trafficking eosinophils other through interstitium. Neutralization RANTES (regulated upon activation, normal T cell expressed secreted) receptor(s) receptor antagonist decreases significantly lymphocyte eosinophil as well mRNA expression RANTES. In contrast, ligands for receptors, macrophage-inflammatory 1α, only slightly BHR. Finally, MCP-1 diminishes drastically inflammation, this correlates pronounced decrease monocyte- lymphocyte-derived mediators. These suggest activate cellular molecular pathways fashion contribute to asthma, individual intervention at levels processes.