DC-SIGN (CD209) Mediates Dengue Virus Infection of Human Dendritic Cells

• DOI: 10.1084/jem.20021840
• Publication Date: 2003-04-07T20:34:31Z
• Authors: Boonrat Tassaneet...; Timothy H. Burgess; Angela Granelli-P...; Christine Trumpfh...; Jennifer Finke; Wellington Sun; Michael A. Eller; Kovit Pattanapany...; Suttipant Sarasom...; Deborah L. Birx; Ralph M. Steinman; Sarah Schlesinger; Mary A. Marovich
• Keywords: DC-SIGN; Antibody-dependent enhancement

Dengue virus is a single-stranded, enveloped RNA that productively infects human dendritic cells (DCs) primarily at the immature stage of their differentiation. We now find all four serotypes dengue use DC-SIGN (CD209), C-type lectin, to infect cells. THP-1 become susceptible infection after transfection DC-specific ICAM-3 grabbing nonintegrin (DC-SIGN), or its homologue L-SIGN, whereas blocked by anti–DC-SIGN antibodies and not other molecules on these Viruses produced are infectious for DC-SIGN– L-SIGN–bearing permissive cell lines. Therefore, may be considered as new target designing therapies block infection.