A human postnatal lymphoid progenitor capable of circulating and seeding the thymus

• DOI: 10.1084/jem.20071003
• Publication Date: 2007-12-11T01:35:19Z
• Authors: Emmanuelle M. Six; Delphine Bonhomme; Marta Monteiro; Kheira Beldjord; Monika Jurkowska; Corinne Cordier-G...; Alexandrine Garrigue; Liliane Dal Cortivo; Benedita Rocha; Alain Fischer; Marina Cavazzana-...; Isabelle André-S...
• Keywords: Lymphopoiesis; Cord blood; Progenitor; Thymocyte

Identification of a thymus-seeding progenitor originating from human bone marrow (BM) constitutes key milestone in understanding the mechanisms T cell development and provides new potential for correcting deficiencies. We report characterization novel lymphoid-restricted subset, which is part lineage-negative CD34+CD10+ population distinct B cell–committed precursors (in view absence CD24 expression). demonstrate that these Lin−CD34+CD10+CD24− progenitors have very low myeloid but can generate B, T, natural killer lymphocytes coexpress recombination activating gene 1, terminal deoxynucleotide transferase, PAX5, interleukin 7 receptor α, CD3ε. These are present cord blood BM also be found throughout life. Moreover, they belong to most immature thymocyte population. Collectively, findings unravel existence postnatal lymphoid-polarized capable migrating thymus.