IL-2–dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells

• DOI: 10.1084/jem.20122462
• Publication Date: 2013-05-07T00:46:45Z
• Authors: Georg Gasteiger; Saskia Hemmers; Matthew A. Firth; Audrey Le Floc’h; Morgan Huse; Joseph C. Sun; Alexander Y. Rude...
• Keywords: Janus kinase 3; Innate lymphoid cell

The emergence of the adaptive immune system took a toll in form pathologies mediated by self-reactive cells. Regulatory T cells (T reg cells) exert critical brake on responses and B lymphocytes to self- foreign antigens. Here, we asked whether are required restrain NK cells, third lymphocyte lineage, whose features combine innate cell properties. Although depletion led systemic fatal autoimmunity, tolerance reactivity strong activating non-self–ligands remained largely intact. In contrast, missing-self were increased absence as result heightened IL-2 availability. We found that rapidly boosted capacity productively engage target enabled weak stimulation. Our results suggest IL-2–dependent adaptive-innate cross talk tunes cytotoxicity limiting availability IL-2.