IL-2–dependent adaptive control of NK cell homeostasis

• DOI: 10.1084/jem.20122571
• Publication Date: 2013-05-07T00:46:45Z
• Authors: Georg Gasteiger; Saskia Hemmers; Paula D. Bos; Joseph C. Sun; Alexander Y. Rude...
• Keywords: Interleukin-7 receptor; Innate lymphoid cell; Homeostasis; Janus kinase 3

Activation and expansion of T B lymphocytes myeloid cells are controlled by Foxp3+ regulatory (T reg cells), their deficiency results in a fatal lympho- myeloproliferative syndrome. A role for the homeostasis innate lymphocyte lineages remained unknown. Here, we report that restrained immature CD127+ NK cells, which had unique ability to up-regulate IL2Rα (CD25) response proinflammatory cytokine IL-12. In addition, observed preferential accumulation mice bearing progressing tumors or suffering from chronic viral infection. expanded an IL-2–dependent manner upon cell depletion were able give rise mature indicating latter can develop through CD25+ intermediate stage. Thus, restrain CD4+ help cells. These findings highlight adaptive control homeostasis.