STAT1 regulates marginal zone B cell differentiation in response to inflammation and infection with blood-borne bacteria

• DOI: 10.1084/jem.20151620
• Publication Date: 2016-11-14T16:41:36Z
• Authors: Ting-Ting Chen; Ming-Hsun Tsai; John T. Kung; Kuo-I Lin; Thomas Decker; Chien-Kuo Lee
• Keywords: STAT1; B-1 cell

Marginal zone B (MZ B) cells can rapidly produce antibody in response to infection with blood-borne encapsulated pathogens. Although TLR-mediated activation of MZ is known trigger humoral immune response, the signal cascade directing this remains undefined. Here, we demonstrate that STAT1 plays an essential role cells. Further, TLR-induced IgM impaired a type I and II IFN-independent manner. activation, proliferation, apoptosis are not affected, both differentiation into plasma production Stat1−/− Interestingly, directly regulates expression Prdm1 (encodes BLIMP-1) by binding its promoter, reduced Restoration BLIMP-1 rescues response. Moreover, mice more susceptible S. pneumoniae infection, which be rescued serum bacteria-primed WT mice. The increased susceptibility also intrinsic requirement Collectively, these results define differential regulation reveal STAT1-dependent, but IFN-independent, during inflammation.