Mannose receptor high, M2 dermal macrophages mediate nonhealing Leishmania major infection in a Th1 immune environment

• DOI: 10.1084/jem.20171389
• Publication Date: 2017-12-15T14:36:49Z
• Authors: Sang Hun Lee; Melanie Charmoy; Audrey Romano; Andrea Paun; Mariana M. Chaves; Frederick O. Cope; David A. Ralph; David L. Sacks
• Keywords: Mannose receptor

The origin and functional specialization of dermal macrophages in cutaneous infections have been little studied. In this paper, we show that a strain Leishmania major (L. Seidman [LmSd]) produces nonhealing lesions conventionally resistant C57BL/6 mice was more efficiently taken up by M2-polarized bone marrow (BM)–derived (BMDMs) vitro mannose receptor (MR)hi vivo compared with healing Friedlin V1). Both steady T helper type 1 (Th1) cell–driven inflammatory states, the MRhi showed M2 characteristics. were radio not replaced monocytes or adult BM-derived cells during infection, but locally maintained IL-4 IL-10. Notably, favored infection BMDMs LmSd MR dependent, genetic deletion selective depletion anti–CSF-1 antibody reversed phenotype. We conclude embryonic-derived, are permissive for parasite growth even strong Th1-immune environment, preferential these plays crucial role severity disease.