The interweaved signatures of common-gamma-chain cytokines across immunologic lineages

570 Biomedical and clinical sciences Biomedical and Clinical Sciences 1.1 Normal biological development and functioning Immunology Health sciences Cell Differentiation Immunological Genome Project Consortium CD8-Positive T-Lymphocytes Medical and Health Sciences Article Vaccine Related Underpinning research Genetics Cytokines Signal Transduction
DOI: 10.1084/jem.20222052 Publication Date: 2023-03-28T13:32:21Z
ABSTRACT
“γc” cytokines are a family whose receptors share a “common-gamma-chain” signaling moiety, and play central roles in differentiation, homeostasis, and communications of all immunocyte lineages. As a resource to better understand their range and specificity of action, we profiled by RNAseq the immediate-early responses to the main γc cytokines across all immunocyte lineages. The results reveal an unprecedented landscape: broader, with extensive overlap between cytokines (one cytokine doing in one cell what another does elsewhere) and essentially no effects unique to any one cytokine. Responses include a major downregulation component and a broad Myc-controlled resetting of biosynthetic and metabolic pathways. Various mechanisms appear involved: fast transcriptional activation, chromatin remodeling, and mRNA destabilization. Other surprises were uncovered: IL2 effects in mast cells, shifts between follicular and marginal zone B cells, paradoxical and cell-specific cross-talk between interferon and γc signatures, or an NKT-like program induced by IL21 in CD8+ T cells.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (58)
CITATIONS (11)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....