Sounding the alarm in the lung with TL1A

• DOI: 10.1084/jem.20240389
• Publication Date: 2024-04-10T13:51:10Z
• Authors: Silvia Pires; Randy S. Longman
• Keywords: 0301 basic medicine; 03 medical and health sciences; Hypersensitivity; Humans; Alarmins; Epithelial Cells; Insights; Lung; Asthma

Environmental airborne antigens are central to the development of allergic asthma, but cellular processes that trigger disease remain incompletely understood. In this report, Schmitt et al. (https://doi.org/10.1084/jem.20231236) identify TNF-like protein 1A (TL1A) as an epithelial alarmin constitutively expressed by a subset lung cells, which is released in response microbial challenge and synergizes with IL-33 drive disease.