Biocompatible nanozyme with dual catalytic activities for high-performance multimodality therapy against glioblastoma

• DOI: 10.1088/1748-605x/adc05b
• Publication Date: 2025-03-13T22:56:16Z
• Authors: Guihong Lu; Xiaoyan Li; Wenfei Xu; Fan Zhang; Xiang Chen; Huibin Wu; Haibing Dai; Feng Li; Weidong Nie
• Keywords: Biocompatible material; Reprogramming; Glucose oxidase

Abstract Nanozymes based on metals have been regarded as a promising candidate in the metabolic reprogramming of low-survival, refractory glioblastoma multiforme (GBM). However, due to size limitations, nanozymes struggle balance catalytic activity with ability cross blood-brain barrier (BBB), limiting their efficiency GBM therapy. Herein, we establish hybrid clustered nanozyme (AM NCs) by cross-linking ultrasmall nano-gold (Au) and manganese oxide (MnO2), which overcomes requirement conflict for integrating activities, long-period circulation, photothermal effect, chemodynamic effect multimodality treatment against GBM. After administered intravenously, overall large-size AM NCs can escape kidney filtration BBB accumulation. Then individual nano-manganese (MnO2) components effectively catalyze H2O2 degradation catalase produce oxygen, is utilized consume glucose oxidase. The generated during Au-catalyzed consumption further facilitates MnO2 activity. Such positive feedback overwhelmingly intervenes metabolism Concurrently, Au-induced released Mn2+-induced contribute eliminating cells. versatile offers feasible strategy intervention GBM.