Induction of Peroxiredoxins in Transplanted Livers and Demonstration of TheirIn VitroCytoprotection Activity

• DOI: 10.1089/ars.2000.2.2-347
• Publication Date: 2008-03-19T17:17:56Z
• Authors: Hungyi Shau; Alejandro Merino; Lawrence Chen; Charles C.-Y. Shih; Steven D. Colquhoun
• Keywords: Cytoprotection; Peroxiredoxin

Peroxiredoxin (Prx)-I and -II belong to a new class of antioxidants. Here, we report that they are induced by ischemia/reperfusion (I/R) in transplanted livers. Hypothesizing Prxs protect liver from oxidative damage, transduced these human genes into murine NIH-3T3 cells. The overexpressed made the cells more resistant t-butylhydroperoxide-induced apoptosis. These results indicate Prx-I Prx-II transplantation process can against oxidant damage tissue culture. Thus, proper genetic manipulations may be useful increasing success rate organ transplantation.