Quantifying the Test-Retest Reliability of Magnetoencephalography Resting-State Functional Connectivity

• DOI: 10.1089/brain.2015.0416
• Publication Date: 2016-05-23T11:43:29Z
• Authors: Pilar Garcés; María Carmen Mart...; Fernando Maestú
• Keywords: Magnetoencephalography

The coordinated activity of the resting-state brain can be evaluated with magnetoencephalography (MEG) for distinct rhythms by performing source reconstruction to estimate activities target regions and employing one many existent functional connectivity (FC) algorithms. Although this procedure has been applied in a great amount studies both healthy pathological populations, reliability such FC estimates is unknown, impairs use MEG at individual level. In study, test-retest resting was exploring within- between-subject variability 16 subjects who underwent three scans. computed after beamforming four popular metrics: phase-locking value (PLV), phase lag index (PLI), direct envelope correlation (d-ecor), leakage correction (lc-ecor). Then, test-restest agreement were intraclass coefficient (ICC) Kendall's W, respectively. Reliability found depend on metric, frequency band, specific link. As general trend, greater PLV theta gamma, lc-ecor d-ecor beta. Further inspection ICC distribution revealed that volume conduction effects could contributing high d-ecor. addition, stronger links more reliable. Overall, encourages further individual-level studies, especially or metrics.