The Major Dopamine D2 Receptor: Molecular Analysis of the Human D2ASubtype

• DOI: 10.1089/dna.1.1989.8.683
• Publication Date: 2011-03-09T21:19:03Z
• Authors: LISA A. SELBIE; GILLIAN HAYES; JOHN SHINE
• Keywords: genomic DNA

The structural diversity of the human D2 dopamine receptor was examined at nucleic acid level. Sequence analysis cDNA clones isolated from brain and pituitary libraries polymerase chain reaction (PCR) rat RNA genomic DNA demonstrate presence a predominant subtype, D2A. D2A subtype differs D2B previously described in RNA, that an additional 29 amino acids are present putative third cytoplasmic domain, region thought to be important for coupling different G-proteins. demonstration intron sequences flanking encoding 29-amino-acid insertion suggests generation two distinct subtypes may arise alternative splicing common sequence.