Antifatigue and Anti-Inflammatory Effects of Cervus elaphus L., Angelica gigas Nakai, and Astragalus membranaceus Bunge Complex Extracts in Physically Fatigued Mice

• DOI: 10.1089/jmf.2022.k.0103
• Publication Date: 2022-12-14T18:00:32Z
• Authors: Wen Yan Huang; Jeong Hoon Pan; Inhye Jeong; Seong Ju Oh; Yong Geon Hyun; Moon Seong Kim; Bok Kyung Han; Jiyoun Hong; Yong Tae Koo; Ki Won Lee; Bora Jin; Dongjin Noh; Sangho Kim; Jae Kyeom Kim; Eui-Cheol Shin; Young Jun Kim
• Keywords: Astragalus; Proinflammatory cytokine; Creatine kinase; Anti-inflammatory; Cervus elaphus

Fatigue is a common complaint among people under stress, causing an array of negative effects on physical function. In this study, we investigated the antifatigue and anti-inflammatory Cervus elaphus L., Angelica gigas Nakai, Astragalus membranaceus Bunge complex extracts (CAA) using treadmill stress test in animal models. The mice were administered various doses CAA (50-200 mg/kg bw per day) once daily for 21 days. After exhaustive exercise, running time CAA-treated increased 1.5 times; fatigue-related biochemical parameters, including lactate dehydrogenase (∼30%), creatine kinase (∼20%), proinflammatory cytokines interleukin (IL)-1β (∼10%), IL-6 (∼10%) serum muscle tissue downregulated compared with those exercised control mice. This study provides strong evidence prevention CAA-induced inflammatory incidences mediated by blockade nuclear factor-κB activation. Collectively, our results indicate that can alleviate symptoms fatigue as effective agent.