Autologous Olfactory Glial Cell Transplantation Is Reliable and Safe in Naturally Occurring Canine Spinal Cord Injury

• DOI: 10.1089/neu.2005.22.1282
• Publication Date: 2005-11-23T21:31:51Z
• Authors: Nick D. Jeffery; Andras Lakatos; Robin J.M. Franklin
• Keywords: Olfactory ensheathing glia; Olfactory nerve

Intraspinal transplantation of olfactory glial cells (OGC) has produced well-defined beneficial effects in experimental rodent models spinal cord injury (SCI) and therefore considerable promise as a treatment for severe SCI human patients. In this study, we used clinical canine cases to determine whether derivation OGC from an autologous source was feasible. From the nerve fiber layer single bulb, were able generate 5 × 106 each patient within 3 weeks. Of population, 72% p75+ OGC, 20% meningeal cells, remainder mainly astrocytes. not associated with any observable long- or short-term complications.