Transactive Response DNA-Binding Protein 43 Abnormalities after Traumatic Brain Injury

• DOI: 10.1089/neu.2017.5491
• Publication Date: 2018-06-14T09:26:33Z
• Authors: Xin Lin Tan; Mujun Sun; Rhys D. Brady; Shijie Liu; Roxana Llanos; Steve Cheung; David K. Wright; Pablo M. Casillas...; Maithili Sashindr...; Terence J. O'Brien; Stuart J. McDonald; Bradley J. Turner; Sandy R. Shultz
• Keywords: 03 medical and health sciences; 0302 clinical medicine

Initial studies have found some evidence for transactive response DNA-binding protein 43 (TDP-43) abnormalities after traumatic brain injury (TBI), and the presence of inclusions consisting TDP-43 are a pathological hallmark amyotrophic lateral sclerosis (ALS), condition associated with TBI. However, no study has characterized changes in phosphorylation, mislocalization, fragmentation (i.e., linked to pathology) TBI, how these relate functional outcomes. Further, TBI affects an individual known predisposition pathology is unknown. Therefore, this examined effects on post-translational processing, localization, behavioral outcomes wild-type (WT) mice mutant